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Large animal advantage

BENEFITS

  1. Accurate, reproducible PV data - users experience tighter confidence intervals for admittance derived volume compared to data calculated by the 'classical' approach.
  2. Study subtle changes in heart function - inter-animal comparisons, drug therapy evaluation, degrees of heart failure, etc.
  3. Fewer animals required per study -improved data collection methods and accuracy checks mean each data set is valuable.
  4. Return on Investment - collect, interpret, and publish more cardiac function data faster!
Explore the Core Features of the Scisense ADVantage PV Loop Sytem
For more information on the theory behind Admittance based volume measurements please click here.

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Automatic calibration of the Volume Signal Eliminates Hypertonic Saline Injection AND Cuvette Calibrations:

- Real time calculations are made by the system to ensure measured volume does not include contributions from the myocardial wall. The ADVantage system measures the phase shift of the electrical field as it passes through both the blood and muscle.

- Varying myocardial wall thicknesses through ED and ES (and therefore parallel conductance) are accounted for in real time.

- Catheter calibration is performed by the system, eliminating the need to place the catheter in the middle of cuvette wells (at 37°C) of different sizes, each of which affect the electrical field in a different way.

ADVantage microprocessor
Catheter Positioning Feedback Facilitates Surgery:

- Due to the position of the aortic valve a catheter in the LV is naturally offset from the centerline. Phase shift measurements indicate this proximity and allow the user to ideally position the catheter.

Absolute Volume in Real-Time

- Mathematically derived algorithms (Wei’s Equation) compensate for both the varying wall thickness throughout the heart cycle as well as the changing proximity to the myocardial wall. These calculations are performed by the ADVantage control unit allowing absolute volume to be output in real time as an analog signal to any acquisition system.

 		Absolute Volume Channel
PV Loops for All Sizes of Hearts:

- New Scisense technology called “variable segment length” (VSL) allows the same catheter to be used in both large and small hearts of the same animal type, reducing experimental costs and uncertainty over which electrode ring spacing is appropriate. Users simply select the spacing that ‘best fits’ the heart they are studying, ensuring the utmost accurate measurements.

 		VSL
Tactile-Button Operation and System Menus increase Ease of Use:

- All of the controls and calibrations are accessible using the wide LCD flash screen with an easy to use menu. Navigation through the menu is designed to step the researcher through the study.

PV Loop System LCD
For information on technical specifications please click here.