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Pressure and pressure volume systems for measuring blood pressure, volume, pv loops, and ECG. Pressure Volume Equipment Hardware, ADVantage, Pressure Measurement

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Synergies between Echo and PV Loop Systems
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Pressure - Volume

Since the mid-1970's the PV loop has steadily become the gold standard as a means to study myocardial contractility, compliance, muscle energetics and other important quantitative measures of function. Approaches such as ultrasonic crystals, magnetic resonance imagine (MRI) and echocardiography have been used to measure instantaneous volume with varying degrees of success. However, these technologies all have severe limitations, particularly during the generation of load independent indices of contractility. Pressure Volume catheter technology has emerged as the most reliable method to generate real-time ventricular PV loops in the intact heart, particularly now as a result of recent advancements in the field through the use of "admittance" instead of the older "conductance" technology. More in-depth information on the role of PV Loops in Cardiovascular Assessment can be found in the "Education" section of this website.

Scisense offers two PV Loop system product lines to fit a variety of budgets and protocols:

These PV loop systems can be configured to work for all sizes of animals, as well as isolated working heart systems. Some of the key differences between the two volume measurement technologies are:

Admittance vs.Conductance PV Loop Systems

Admittance-PV Systems
(the Scisense ADVantage™)

Conductance PV Systems
(Traditional Technology)

Absolute Volume (ml/µl)
Yes
No
Relative Volume (rvu's)
Optional
Yes
Real Time
Yes
No
Saline Bolus Required
No
Yes
Cuvette Required
No
Yes
Self-Calibrating
Yes
No
Catheter Position Feeback
Yes
No
Inter-Animal Comparison
Yes
No
"Pre & Post" Studies
Yes
No
MI Studies
Yes
No
Enlarged Hearts
Yes
Optional
Isolated Working Hearts
Yes
Optional
Catheter Type
Admittance (FTE)
Conductance (FTS)

Overall, the Admittance technology contained exclusively in the Scisense ADVantage product line represents a great technology leap forward in pressure volume measurement studies. Now available for all sizes of animals from mice to pigs, sheep, etc., the technology brings a number of new important benefits to cardiovascular assessment:

  • Increased accuracy of results
  • Repeatable results with lower standard deviations
  • Fewer animals required
  • Reduced project times

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